From Interstate 10 at Indio, take the Dillon Road offramp and turn south. At the first stoplight, just over the railroad tracks, turn left (southeast) onto Highway 111 for about 25 miles. Along the way: stay on Highway 111 at its junction with Highway 86, by taking the left fork (toward Nyland). Proceed on Highway 111 through the towns of Coachella, Theral and Mecca, to the Salton Sea. About 10 miles southeast of Mecca, look for the Park Headquarters for the Salton Sea State Recreation Area on your right. Opposite park headquarters: turn left onto Parkside Drive. Take Parkside to the end (about 2 miles) and turn right onto Desert Aire. Follow Desert Aire to its end, then turn left onto the unnamed dirt road. Take the next left fork and stay on the dirt road to Rancho Dos Palmas.

For in depth information about Dos Palmas Preserve, please visit their website.
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